Thyroid hormones (TH) are necessary for various metabolic functions. These are also required for proper kidney growth and development. In contrast, the kidney is not just an organ for thyroid hormone metabolism and elimination, but it is also a target organ for various iodothyronine effects. Thyroid dysfunction alters glomerular and tubular functioning, as well as electrolyte and water homeostasis.
Hypothyroidism is characterised by a decrease in glomerular filtration, hyponatremia, and a change in the ability to excrete water. Excess TH causes an increase in glomerular filtration rate and renal plasma flow. Thyroid function is significantly altered as a result of renal illness. It has been shown that several forms of glomerulopathies are associated with both hyper- and hypothyroidism. The tubulointerstitial disease has been linked to functional thyroid problems less commonly. Nephrotic syndrome is characterised by variations in TH concentrations caused mostly by protein loss in the urine. Acute and chronic renal illness both have significant impacts on the hypothalamus-pituitary-thyroid axis. Pituitary thyrotropin (TSH) secretion is reduced in uremia.
Data from recent pieces of evidence suggests that TH, particularly T3, can be used to predict survival in patients with kidney disease.
Hypothyroidism in Chronic Kidney Disease
In each other’s illness states, thyroid and kidney functions interact in various ways. Thyroid hormones have an impact on renal development and functioning. Thyroid hormones have both pre-renal and intrinsic renal effects, increasing renal blood flow and glomerular filtration rate (GFR). Hypothyroidism causes decreased GFR, whereas hyperthyroidism causes enhanced GFR and increased renin-angiotensin-aldosterone activation. Chronic kidney disease (CKD) is distinguished by a low T3 condition, which is now recognised as an atypical nonthyroidal ailment. Primary hypothyroidism and subclinical hypothyroidism are more common in CKD patients.
The physiological benefits of hypothyroidism in CKD, as well as the risk of CKD progression with hyperthyroidism, underscore the importance of taking a careful approach to treating thyroid hormone abnormalities in CKD. Thyroid dysfunction is often linked to glomerulonephritis by autoimmune pathogenesis. Several medications have the potential to impair thyroid and renal function. There have been few reports of connections between thyroid and renal cancers. For effective patient therapy, both nephrologists and endocrinologists must have a thorough, understanding of all of these interconnections.
Thyroid hormones have long been known to have a variety of circulatory consequences. However, considerable knowledge gaps exist regarding the precise molecular and biochemical mechanisms regulating these effects, as well as the best techniques for managing thyroid function anomalies in patients with and without prior cardiovascular disease. The thyroid hormone has an immediate impact on heart function, blood vessel function, and cholesterol levels. Hypothyroidism symptoms include a slowing heart rate, constriction of the blood vessels and elevated blood pressure, fluid retention and oedema, and increased cholesterol levels.
Severe hypothyroidism cases can cause heart failure and death in certain cases. Hypothyroidism, when treated with thyroid hormone replacement, can reverse most of the negative effects. However, over-medication for hypothyroidism can result in high thyroid levels and fast or irregular heart rates. There are a few clinical studies that have looked at the risk of heart problems in terms of the duration of the disease and treatment of hypothyroidism.
Kidney Disease treatment in Ayurveda
In short, these three disorders are related to each other. We can correct these disorders with the use of Ayurvedic medicines. Ayurveda is our ancient Indian medicine system. It has a strong base to treat many diseases and conditions. Ayurveda identifies the cause of the disease. After determining the cause and the damage caused by it, Ayurvedic kidney treatment procedures. It uses herbs and other herbal products to treat diseases. It also suggests a healthy lifestyle that would have long-term effects on maintaining your health and keeping you away from diseases.
Kidney Disease treatment in Ayurveda has helped many people recover from kidney diseases.